Proteases - Aminopeptidases - Subtilisin/Kex2p-like proprotein convertase - DPP-4
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B5437 Decanoyl-RVKR-CMKTarget: Subtilisin/Kex2p-like proprotein convertaseSummary: 枯草杆菌蛋白酶/Kex2p样前蛋白转化酶抑制剂
- B3941 Talabostat mesylate2 CitationTarget: DPP-4Summary: DPP4抑制剂
- A8650 Saxagliptin中文名: 沙格列汀Target: DPP-4Summary: DPP4抑制剂
- A8621 Bestatin hydrochloride中文名: 盐酸乌苯美司Target: AminopeptidasesSummary: 氨肽酶N(APN/CD13)和氨肽酶B抑制剂。
- A3865 Teneligliptin hydrobromide中文名: 氢溴酸替格列汀Target: DPP-4Summary: DDP4抑制剂
- A4355 Tosedostat (CHR2797)1 Citation中文名: 托舍多特Target: AminopeptidasesSummary: 氨肽酶(Aminopeptidase)抑制剂
- A4038 Alogliptin (SYR-322)1 Citation中文名: 阿格列汀Target: DPP-4Summary: DPP-4抑制剂
- A4036 Sitagliptin phosphate monohydrate5 Citation中文名: 磷酸西他列汀一水合物Target: DPP-4Summary: DPP-4抑制剂
- A2575 Bestatin中文名: 乌苯美司Target: AminopeptidasesSummary: 氨肽酶抑制剂