Neuroscience
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A1004 Amyloid Precursor C-Terminal PeptideSummary: 用于β淀粉样蛋白的产生
- A1003 Amyloid β-Protein (1-15)Summary: β淀粉样蛋白(1-15),淀粉样蛋白的主要成分。
- A1002 Beta-Amyloid (1-11)Summary: 淀粉样变性肽
- A1132 β-PompilidotoxinTarget: sodium channelsSummary: 减慢Na+通道失活。
- C4812 N-tert-butyl-α-PhenylnitroneSummary: COX-2 inhibitor
- A1131 COG 133Summary: 载脂蛋白E(ApoE)模拟肽
- A1129 Parathyroid hormone (1-34) (human)中文名: 特立帕肽Summary: 提高血钙水平
- C5755 (S)-Naproxen中文名: 萘普生Summary: 非选择性COX抑制剂
- C5736 Valeroyl SalicylateSummary: 环氧合酶-1(COX-1)的选择性不可逆抑制剂
- C5733 6-methoxy Naphthalene Acetic AcidSummary: 竞争性和非选择性COX抑制剂