Neuroscience
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A1124 Amyloid Beta-Peptide (1-40) (human)1 CitationSummary: β淀粉样蛋白
- A1123 Amyloid Beta-Peptide (12-28) (human)Summary: β淀粉样蛋白肽
- C5591 Indomethacin N-octyl amideSummary: 有效但非选择性的COX-1和COX-2抑制剂
- C5581 O-Acetyl Salicylhydroxamic AcidSummary: COX-1和COX-2的不可逆非选择性抑制剂
- C5551 FR122047 (hydrate)Summary: COX-1的选择性抑制剂
- C5582 3,4-dihydro NaratriptanSummary: 选择性血清素5-HT1B激动剂
- C5633 N-(4-acetamidophenyl)-Indomethacin amideSummary: COX-2抑制剂
- C5629 N-(3-pyridyl)-Indomethacin amideSummary: COX-2抑制剂
- C5628 N-(2-phenylethyl)-Indomethacin amideSummary: COX-2抑制剂
- C5515 Eicosatetraynoic AcidSummary: 环氧合酶和脂氧合酶的非特异性抑制剂