Parathyroid hormone (1-34) (human)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mg | ￥680.00 | 现货 | |
| 5mg | ￥833.00 | 现货 | |
| 10mg | ￥1147.00 | 现货 | |
| 25mg | ￥2409.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Parathyroid hormone (1-34) (human),(C181H291N55O51S2),是序列为H2N-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-OH的多肽,分子量为4117.72.甲状旁腺激素(PTH)是由甲状旁腺主细胞分泌的含有84个氨基酸的多肽.它的作用是增加血液中钙离子(Ca2+)的浓度,而降钙素(由甲状腺的滤泡旁细胞(C细胞)产生的激素)的作用是降低钙离子浓度.PTH通过作用于甲状旁腺激素受体1和甲状旁腺激素受体2来增加血液中钙离子的浓度(1).甲状旁腺激素可以提高骨骼大型储存库中的钙离子释放,调节血清钙(2).它促进钙\镁离子经远端小管和髓袢升支粗段的主动重吸收(3).它通过增加活性维生素D的生成来促进肠道中钙离子的吸收.
参考文献:
1.Bieglmayer C, Prager G, Niederle B (October 2002). "Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy". Clin. Chem. 48 (10): 1731–8.
2.PooleK, Reeve J (2005). "Parathyroid hormone - a bone anabolic and catabolic agent". Curr Opin Pharmacol 5 (6): 612–7.
3.Coetzee M, Kruger MC (May 2004). "Osteoprotegerin-receptor activator of nuclear factor-kappaB ligand ratio: a new approach to osteoporosis treatment?". South. Med. J. 97 (5): 506–11.
产品性质
| 物理外观 | A solid |
| CAS号 | 52232-67-4 |
| 分子式 | C181H291N55O51S2 |
| 分子量 | 4117.75 |
| 溶解度 | ≥399.3 mg/mL in DMSO; insoluble in EtOH; ≥19.88 mg/mL in H2O |
| 存储条件 | -20°C干燥 |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 甲状旁腺激素通过溶解骨骼中的盐分并阻止其从肾脏排出，从而提高钙含量。 |
| 靶点 | Neuroscience Peptides |
生物相关数据
质量控制
APExBIO 顾客使用本产品发表的 8 篇科研文献
3. Yuefu Chen, Shuxin Sun, et al. "Low-intensity pulsed ultrasound and parathyroid hormone improve muscle atrophy in estrogen deficiency mice." Ultrasonics. 2023 Jul:132:106984. PMID: 36944299
4. Qi Lou, Kaizheng Jiang, et al. "The RIG-I-NRF2 axis regulates the mesenchymal stromalniche for bone marrow transplantation." Blood. 2022 Mar 8;blood.2021013048. PMID: 35259210
5. Ziyue Qin, Shu Hua, et al. "Parathyroid hormone promotes the osteogenesis of lipopolysaccharide-induced human bone marrow mesenchymal stem cells through the JNK MAPK pathway." Biosci Rep. 2021 Aug 27;41(8):BSR20210420. PMID: 34350461
6. Yuli Wang, Lintong Huang, et al. "Parathyroid hormone ameliorates osteogenesis of human bone marrow mesenchymal stem cells against glucolipotoxicity through p38 MAPK signaling." IUBMB Life. 2021 Jan;73(1):213-222. PMID: 33249758
7. Zhiyuan Zou, Le Wang, et al. "Simultaneous incorporation of PTH (1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration." Bioact Mater. 2020 Dec 7;6(6):1839-1851. PMID: 33336115
8. Ge X, Li Z, et al. "Parathyroid hormone enhances the osteo/odontogenic differentiation of dental pulp stem cells via ERK and P38 MAPK pathways." J Cell Physiol. 2020;235(2):1209–1221. PMID: 31276209
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