Amyloid Precursor C-Terminal Peptide

淀粉样前体C-端肽（APP）（C86H118N20O27S）的氨基酸序列为Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn。尽管它可作为突触形成、神经可塑性和铁输出的调节子，但APP最重要的功能是作为前体分子，其蛋白水解产生β淀粉样蛋白（Aβ），一个含37-49个氨基酸的多肽。Aβ的淀粉样原纤维形式是阿尔茨海默病患者脑中发现的淀粉样蛋白斑块的主要成分。因此，Aβ可能通过MAPKs和NF-κB依赖的星形胶质细胞增生，造成阿尔茨海默病的发病。最近发现，APP与关节炎动物相关，诱导继发炎症，可能引起局部损伤。

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