β-Pompilidotoxin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
β-Pompilidotoxin的化学式为C71H124N22O17,氨基酸序列为H2N-Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu-amide,分子量为1557.88。Pompilidotoxin是来源于蛛蜂毒液的毒素,可以减慢Na+通道的失活。α-Pompilidotoxin(α-PMTX)是从蛛蜂的毒液提取得到的。β-Pompilidotoxin(β-PMTX)来源于另外一种黄蜂的毒液(Batozonellus maculifrons)(1)。α-PMTX与其他毒素没有结构同源性,它缺乏二硫键,这种二硫键存在于其他可以与钠通道相互作用的毒素中,如海葵毒素或蝎毒素(2)。α-和β-PMTX减慢神经元钠通道的失活,但不作用于心脏钠通道,有可能通过结合钠通道外表面的神经毒素受体位点3发挥作用(3)。β-PMTX的效力比α-PMTX更高。通过减慢钠通道的失活,PMTXs可以增强龙虾神经肌肉终板的突触传递。
Figure1 Formula of β-Pompilidotoxin
参考文献:
1. Konno K, Hisada M, Itagaki Y, Naoki H, Kawai N, Miwa A, Yasuhara T, Takayama H (1998). "Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms". Biochem Biophys Res Commun. 250 (3): 612–6.
2. Sahara Y, Gotoh M, Konno K, Miwa A, Tsubokawa H, Robinson HP, Kawai N (2000). "A new class of neurotoxin from wasp venom slows inactivation of sodium current". Eur J Neurosci. 12 (6): 1961–70.
3. Kawai N, Konno K (2004). "Molecular determinants of two neurotoxins that regulate sodium current inactivation in rat hippocampal neurons". Neurosci Lett. 361 (1-3): 44–6.
Physical Appearance | A solid |
Storage | Desiccate at -20°C |
M.Wt | 1557.9 |
Cas No. | 216064-36-7 |
Formula | C71H124N22O17 |
Synonyms | Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu |
Solubility | ≥155.8 mg/mL in DMSO; insoluble in EtOH; ≥22.05 mg/mL in H2O |
Chemical Name | β-Pompilidotoxin |
SDF | Download SDF |
Canonical SMILES | CCC(C)C(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)N)NC(=O)C(CCCN=C(N)N)N |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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