Neuroscience
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A1031 Myelin Basic Protein (68-82), guinea pigSummary: 对神经髓鞘的形成具有重要作用。
- A1028 Cadherin Peptide, avianSummary: 在细胞粘附中发挥作用。
- A1023 Laminin (925-933)2 CitationSummary: 细胞外基质糖蛋白
- A1022 GTP-Binding Protein Fragment, G alphaSummary: GTP结合蛋白片段,Gα,将GTP水解为GDP。
- A1017 Adrenorphin, Free AcidSummary: μ/κ opioid 受体激动剂
- A1016 Ac-Endothelin-1 (16-21), humanSummary: ETA/ ETB受体激动剂,血管收缩剂。
- A1015 alpha-EndorphinSummary: 神经递质
- A1014 Beta-Lipotropin (1-10), porcineSummary: 吗啡类似物
- A1012 Dynorphin (2-17), amide, porcineSummary: 疼痛反应的调节剂。
- A1005 Beta-Sheet Breaker Peptide iAβ5Summary: 抑制淀粉样蛋白生成的多肽