Neuroscience
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- C5734 Trimipramine (maleate)中文名: 三甲丙咪嗪马来酸盐Summary: 组胺H1受体的有效拮抗剂
- C5314 cis-Flupenthixol (hydrochloride)中文名: 盐酸氟哌噻吨Summary: 多巴胺D2受体拮抗剂
- C5707 Myosmine中文名: 麦斯明Summary: 神经元烟碱乙酰胆碱受体激动剂
- C5271 AL 34662Summary: 有效的5-HT2受体激动剂
- C5264 (S)-FlurbiprofenSummary: COX-1和COX-2抑制剂
- C5214 6-fluoro-DL-TryptophanSummary: 5-羟色胺(5-HT)合成抑制剂
- C4947 N-(3-hydroxyphenyl)-Arachidonoyl amideSummary: COX-2的选择性不可逆抑制剂
- C4910 SpermineSummary: 混合NMDA谷氨酸受体激动剂/拮抗剂
- B7872 5-MethoxytryptamineSummary: A complete agonist of 5-HT1, 5-HT2, 5-HT4, 5-HT6 and 5-HT7 receptors.
- A1121 Melanocyte stimulating hormone release inhibiting factorSummary: 促黑素释放抑制因子