Metabolism - Nampt - Lactate Dehydrogenases (LDH) - Fatty-acid-binding proteins (FABPs) - Cytochrome P450 (CYP450)
Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.
清除全部
- A8703 IsosafroleTarget: Lactate Dehydrogenases (LDH)Summary: stiripentol类似物,有效的LDH抑制剂。
- A8704 Stiripentol中文名: 司替戊醇Target: Lactate Dehydrogenases (LDH)Summary: LDH抑制剂
- B5963 7-Ethoxyresorufin中文名: 乙氧基试卤灵,7-乙氧基-3H-吩恶嗪-3-酮Target: Cytochrome P450 (CYP450)Summary: CYP1A特异性底物
- B4929 GSK 2837808ATarget: Lactate Dehydrogenases (LDH)Summary: 乳酸脱氢酶A(LDHA)抑制剂
- B7794 BMS 3094032 CitationTarget: Fatty-acid-binding proteins (FABPs)Summary: FABP4抑制剂
- A1718 Posaconazole中文名: 泊沙康唑Target: Cytochrome P450 (CYP450)|sterol demethylaseSummary: 甾醇 C14ɑ去甲基化酶抑制剂
- A3374 Dronedarone中文名: 决奈达隆Target: Cytochrome P450 (CYP450)|sodium channel|adrenergic receptor|potassium channel|calcium channelSummary: CYP3A4和2D6抑制剂
- A4381 FK866 (APO866)1 Citation中文名: 达珀利奈Target: NamptSummary: NAMPT抑制剂
- A4322 Clarithromycin中文名: 克拉霉素Target: Cytochrome P450 (CYP450)Summary: CYP3A抑制剂
- A4316 Ketoconazole中文名: 酮康唑Target: Cytochrome P450 (CYP450)Summary: 环孢菌素氧化酶和睾酮6β-羟化酶的抑制剂