Membrane Transporter/Ion Channel - CFTR - AMPA Receptors - Cytochrome P450 (CYP450)
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B7590 Quinidine中文名: 奎尼丁Target: Voltage-gated Sodium (NaV) Channels|Cytochrome P450 (CYP450)Summary: 降低Na+和K+通道电流
- B1087 GlyH-101Target: CFTRSummary: CFTR Inhibitor II
- A8637 IOWH-032Target: CFTRSummary: CFTR抑制剂
- A8351 VX-809中文名: 鲁玛卡托Target: CFTRSummary: CFTR调节剂
- A2664 VX-661Target: CFTRSummary: F508del CFTR校正子
- A3956 ZosuquidarTarget: P-glycoprotein (P-gp)|Cytochrome P450 (CYP450)Summary: MDR调节剂
- A3176 Ampalex中文名: 安帕来斯Target: AMPA ReceptorsSummary: 促智药