JAK/STAT Signaling - Cancer - Ovarian Cancer
The JAK (Janus kinase) / STAT (signal transducer and activator of transcription) signaling pathway transduce signals that are essential for development, cellular differentiation and homeostasis. This pathway plays a critical role in cytokine receptor systems, regulating growth, survival and pathogen resistance. JAK is a family of non-receptor protein tyrosine kinases, consisting of JAK1, JAK2, JAK3 and TYK2 (Tyrosine Kinase-2). STATs are transcription factors that activated following recruitment to an activated receptor complex, seven STAT proteins have been identified: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.
Various ligands including cytokines (e.g. interferons and interleukins), hormones (e.g. erythropoietin and growth hormone) and their cell surface receptors activate JAK proteins, which autophosphorylate, and then phosphorylate the receptor. Subsequently, JAKs phosphorylate a specific tyrosine residue on the STAT protein, promoting dimerization via SH2 domains. The activated STATs form homo-/heterodimers and translocate to the nucleus to trigger target gene transcription. In addition, suppressors of cytokine signaling (SOCS) family inhibit receptor signaling via homologous or heterologous feedback regulation. Dysregulation in JAK/STAT signaling is associated with diseases such as atherosclerosis, immunodeficiencies and cancer.
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- A3962 AZD1208Target: PimSummary: PIM激酶抑制剂
- A3937 XL019Target: JAKSummary: 有效的JAK2选择性抑制剂
- A3556 LKB1 (AAK1 dual inhibitor)Target: PimSummary: Pim-1激酶抑制剂
- A3433 Gefitinib hydrochloride中文名: 盐酸吉非替尼Target: EGFRSummary: EGFR有效的抑制剂
- A3320 CO-1686 (AVL-301)1 CitationTarget: EGFRSummary: EGFR抑制剂
- A4152 BMS-911543Target: JAKSummary: JAK2抑制剂
- A4150 WHI-P154Target: VEGFR|Src|EGFR|JAKSummary: JAK3抑制剂
- A4148 NVP-BSK805 2HClTarget: JAKSummary: JAK2抑制剂
- A4147 LY2784544Target: Aurora Kinases|FLT3|VEGFR|FGFR|Trk Receptors|JAK|ALK|TYK2|MUSK|MAP3KSummary: JAK2抑制剂
- A4140 WP1066Target: STAT|JAKSummary: 细胞通透的JAK2/STAT3抑制剂。