HDAC - Histone Deacetylases (HDACs) - Colon Cancer - Breast Cancer
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
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- B4794 Santacruzamate A (CAY10683)Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4500 TCS HDAC6 20b1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6的选择性抑制剂
- A4496 NSC 3852Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4105 M3441 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4099 Valproic acid sodium salt (Sodium valproate)中文名: 丙戊酸钠Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4098 PCI-24781 (CRA-024781)Target: Histone Deacetylases (HDACs)Summary: Pan-HDAC抑制剂
- A4097 CUDC-907中文名: 非美诺司他Target: Histone Deacetylases (HDACs)|PI3KSummary: PI3K/HDAC抑制剂
- A4090 JNJ-264815853 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4083 Rocilinostat (ACY-1215)1 CitationTarget: Histone Deacetylases (HDACs)Summary: 选择性的HDAC6抑制剂
- A8176 Apicidin2 CitationTarget: Histone Deacetylases (HDACs)Summary: 有效的HDAC抑制剂