DNA Damage/DNA Repair - Chronic Lymphocytic Leukemia - Epilepsy - Multiple Myeloma - Colon Cancer
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B4794 Santacruzamate A (CAY10683)Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- B1251 Valproic acid中文名: 丙戊酸Target: Histone Deacetylases (HDACs)Summary: HDAC1抑制剂
- A8624 CGK733Target: ATM/ATRSummary: ATM/ATR抑制剂
- A8315 NU7441 (KU-57788)4 CitationTarget: PI3K|DNA-PKSummary: DNA-PK抑制剂
- A1769 KU-00606481 CitationTarget: PI3K|DNA-PKSummary: DNA-PK/PI3-K双重抑制剂
- A4500 TCS HDAC6 20b1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6的选择性抑制剂
- A4098 PCI-24781 (CRA-024781)Target: Histone Deacetylases (HDACs)Summary: Pan-HDAC抑制剂
- A4071 Fluorouracil (Adrucil)3 Citation中文名: 氟尿嘧啶Target: Thymidylate SynthaseSummary: 胸苷酸合成酶抑制剂,抗肿瘤药物。
- A4093 ITF2357 (Givinostat)2 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4090 JNJ-264815853 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC抑制剂