DNA Damage/DNA Repair - Animal Experiments
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- A8802 (S)-Crizotinib4 CitationTarget: MTH1Summary: MTH1抑制剂
- A8649 NU 7026Target: PI3K|DNA-PK|ATMSummary: 有效的、竞争性DNA-PK抑制剂
- A8648 Oxaliplatin3 Citation中文名: 奥沙利铂Summary: 抗肿瘤剂
- A8647 Capecitabine中文名: 卡培他滨Summary: DNA,RNA和蛋白质合成抑制剂
- A8644 Acyclovir中文名: 阿昔洛韦Target: HSVSummary: 抗病毒剂
- A8601 Tankyrase Inhibitors (TNKS) 49Target: TankyrasesSummary: 端锚聚合酶抑制剂
- A8547 Tubastatin A HCl1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6(组蛋白去乙酰化酶6)抑制剂
- A8405 Cytarabine1 Citation中文名: 阿糖胞苷Summary: cytotoxic agent, blocks DNA synthesis
- A8437 Gemcitabine1 Citation中文名: 吉西他滨Summary: DNA合成抑制剂
- A8336 KU-600192 CitationTarget: ATM/ATRSummary: ATM激酶抑制剂