Cell Cycle/Checkpoint - PAK - LRRK2 - ATM/ATR - PKC
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B3523 Fasudil中文名: 法舒地尔Target: ROCK|PKC|PKG|PKA|Myosin light chain kinases (MLCKs)Summary: 钙拮抗剂
- B2169 IPA-31 CitationTarget: PAKSummary: 非竞争性Pak1抑制剂
- B1162 FRAX5971 CitationTarget: PAKSummary: ATP竞争性的PAK抑制剂
- B1383 VE-8222 CitationTarget: ATM/ATRSummary: ATR抑制剂
- A8626 ETP-46464Target: PI3K|mTOR|DNA-PK|ATM/ATRSummary: ATR抑制剂
- A8624 CGK733Target: ATM/ATRSummary: ATM/ATR抑制剂
- A8336 KU-600192 CitationTarget: ATM/ATRSummary: ATM激酶抑制剂
- A1986 Nu 6027Target: Cyclin-Dependent Kinases|ATM/ATRSummary: 有效的ATR/CDK选择性抑制剂
- A3716 PF-37583091 CitationTarget: PAKSummary: PAK4抑制剂
- A3210 AZ201 CitationTarget: ATM/ATRSummary: ATR抑制剂