Cell Cycle/Checkpoint - Colorectal Cancer - Pancreatic Cancer - Colon Carcinoma
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B1088 LY2606368Target: ChkSummary: CHK1抑制剂
- B1162 FRAX5971 CitationTarget: PAKSummary: ATP竞争性的PAK抑制剂
- B1288 RigosertibTarget: PI3K|PLKSummary: PI3K/PLK1抑制剂
- B1437 PF-477736Target: ChkSummary: Chk1抑制剂
- A8681 Ro3280Target: PLKSummary: PLK1高选择性抑制剂
- A8316 PD 0332991 (Palbociclib) HCl5 Citation中文名: 帕博西尼Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A5459 PHA-7938871 CitationTarget: Cyclin-Dependent KinasesSummary: Pan-Cdk抑制剂
- A1352 Zoledronic Acid中文名: 唑来膦酸Target: Farnesyl Diphosphate SynthasesSummary: 含氮二磷酸盐
- A3721 PHA-767491Target: Cyclin-Dependent Kinases|MK2|Cdc7Summary: Cdc7 / CDK9抑制剂
- A3214 AZD11521 CitationTarget: Aurora KinasesSummary: Aurora B激酶抑制剂