Cell Cycle/Checkpoint - Selective
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B3707 ML167Target: ClkSummary: Clk4抑制剂
- B3694 K-Ras(G12C) inhibitor 6Target: KRAS G12CSummary: K-Ras (G12C)抑制剂
- A8882 THZ112 CitationTarget: Cyclin-Dependent KinasesSummary: CDK7共价抑制剂
- B1088 LY2606368Target: ChkSummary: CHK1抑制剂
- B1463 KPT-276Target: nuclear export|CRM1Summary: CRM1抑制剂
- B2169 IPA-31 CitationTarget: PAKSummary: 非竞争性Pak1抑制剂
- B1035 Dolastatin 10中文名: 尾海兔素10Target: Microtubules/TubulinsSummary: 抗肿瘤剂
- B1162 FRAX5971 CitationTarget: PAKSummary: ATP竞争性的PAK抑制剂
- B1232 XL413Target: Cdc7Summary: Cdc7抑制剂
- B1236 BML-277Target: ChkSummary: 有效的Chk2选择性抑制剂