Apoptosis - Bcl-2 - PDGFR - cysteine protease - Nrf2/ARE signal
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
- B5978 BDA-366Target: Bcl-2Summary: BCL2 BH4 结构域的选择性拮抗剂
- B5846 Radotinib(IY-5511)中文名: 雷多替尼Target: PDGFR|Bcr-AblSummary: Bcr-Abl酪氨酸激酶抑制剂
- B4902 (+)-Apogossypol中文名: 變棉子酚,阿朴棉子酚,变棉子酚Target: Bcl-2Summary: Bcl-2家族蛋白抑制剂
- A8170 Z-FA-FMKTarget: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- A8236 Regorafenib4 Citation中文名: 瑞戈非尼Target: Raf|VEGFR|PDGFR|c-Kit|RETSummary: VEGFR/PDGFR/FGFR/mutant Kit/RET/Raf-1抑制剂
- A3750 Regorafenib hydrochloride中文名: 瑞戈非尼盐酸盐Target: Raf|VEGFR|PDGFR|c-Kit|c-RETSummary: 酪氨酸激酶抑制剂
- A4199 Sabutoclax2 CitationTarget: Bcl-2|Mcl-1|Bfl-1Summary: Pan-Bcl-2抑制剂
- A4200 Apogossypolone (ApoG2)2 CitationTarget: Bcl-2|Bcl-xl|Mcl-1Summary: Bcl-2的非肽类小分子抑制剂
- A4194 Obatoclax mesylate (GX15-070)1 Citation中文名: 奥巴克拉甲磺酸盐Target: Bcl-2Summary: 强效的BCL-2抑制剂
- A4234 TW-371 CitationTarget: Bcl-2|Bcl-xl|Mcl-1Summary: Bcl-2抑制剂,抑制Bcl-2、Bcl-XL和Mcl-1。