Ubiquitination/ Proteasome - Topoisomerases - p97 - Geranylgeranyltransferase I - Proteasome
Ubiquitination is a process in targeting proteins for degradation by the proteasome. Ubiquitin (Ub) is a 76 amino acid polypeptide which can be covalently attached to various cellular proteins by the ubiquitination process. This ubiquitin-proteasome system plays a vital role in cell division, growth, differentiation, transcriptional regulation, apoptosis and immunity etc. Three main types of enzymes are involved in the process of ubiquitination. In the first step, activation of ubiquitin is carried out by ubiquitin-activating enzyme (E1) through an ATP-dependent reaction. In the second step, the activated ubiquitin is transferred from E1 to ubiquitin-conjugating enzyme (E2). In the final step, the ubiquitin protein ligase (E3) is required for labeling the ubiquitin to target substrate protein. An isopeptide bond is formed between the carboxyl terminus of ubiquitin and the ε-amino group of a lysine residue in the target protein.
Once the substrate protein is labeled, proteasome will bind to a polyubiquitin chain, allowing the degradation of the labeled protein. The polyubiquitinated target protein is then recognized and degraded by the 26S proteasome. Deubiquitinating enzymes (DUBs) reverse the process of ubiquitination by removing ubiquitin from its substrate protein. Dysregulation of the ubiquitin-proteasome system has been linked to cancer, diabetes, cardiovascular and neurodegenerative diseases etc.
清除全部
- B6032 CB-5083Target: p97Summary: p97抑制剂
- B6026 VR23Target: ProteasomeSummary: 蛋白酶抑制剂
- B1492 PYR-412 CitationTarget: ProteasomeSummary: 泛素活化酶(E1)抑制剂
- A4443 Gliotoxin1 CitationTarget: 20S proteasomal chymotrypsin|Geranylgeranyltransferase I|FarnesyltransferaseSummary: 20S蛋白酶体抑制剂
- A8163 AM 1142 CitationTarget: ProteasomeSummary: 20S蛋白酶体抑制剂
- A1933 Carfilzomib (PR-171)10 Citation中文名: 卡非佐米Target: ProteasomeSummary: 蛋白酶体抑制剂
- A2614 Bortezomib (PS-341)24 Citation中文名: 硼替佐米Target: ProteasomeSummary: 蛋白酶体抑制剂
- A2612 MG-1151 CitationTarget: ProteasomeSummary: 蛋白酶体抑制剂
- A4010 Salinosporamide A (NPI-0052, Marizomib)Target: ProteasomeSummary: 20S蛋白酶体抑制剂
- A4011 ONX-0914 (PR-957)6 CitationTarget: ProteasomeSummary: 免疫蛋白酶体(immunoproteasome)抑制剂