Tyrosine Kinase - ErbB-2 - Fyn - IRAK - DCLK2
Receptor tyrosine kinases bind to extracellular ligands/growth factors, which promotes receptor dimerization and autophosphorylation of receptor tyrosine residues. This triggers a cascade of downstream events through phosphorylation of intracellular proteins that ultimately transduce the extracellular signal to the nucleus, causing changes in gene expression. Receptor tyrosine kinases include EGFR/ErbB, PDGFR, VEGFR, FGFR and MET subfamilies etc. Dysfunctions in tyrosine phosphorylation are linked to oncogenic transformation. In additions, various adaptor and effector proteins couple to carboxy-terminal of an active kinase. For instance, binding of the GRB2 adaptor protein activates EGFR and MAPK/ERK signaling.
Non-receptor tyrosine kinases involve many well-defined proteins (e.g. the Src family kinases, c-Abl, and Jak kinases) and other kinases which regulates cell growth and differentiation. For example, Src family kinases are curial for activating and inhibitory pathways in the innate immune response.
- B5839 SU6656Target: Src|Lyn|YES|FynSummary: Src 酪氨酸激酶抑制剂
- A3967 Lapatinib Ditosylate中文名: 二苯磺酸拉帕替尼Target: EGFR|ErbB-2Summary: EGFR / HER2抑制剂
- A3558 LRRK2-IN-11 CitationTarget: LRRK2|DCLK2Summary: LRRK2抑制剂
- A3505 IRAK-1-4 Inhibitor I3 CitationTarget: IRAKSummary: IRAK-1/4抑制剂
- A3504 IRAK inhibitor 6Target: IRAKSummary: IRAK-4抑制剂
- A3503 IRAK inhibitor 4Target: IRAKSummary: IRAK抑制剂
- A3502 IRAK inhibitor 3Target: IRAKSummary: IRAK抑制剂
- A3500 IRAK inhibitor 12 CitationTarget: IRAKSummary: IRAK-4抑制剂