IRAK inhibitor 4
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IRAK inhibitor 4是白细胞介素-1受体相关激酶（IRAK，interleukin-1 receptor-associated kinase）抑制剂[1]。
IRAK-4属于白细胞介素-1受体相关激酶家族，是信号传导途径中的关键组分。IRAK-4介导白细胞介素-1受体（IL-1R）、白细胞介素-18受体（IL-18R）和Toll样受体（TLR）下游的信号转导。 IRAK-4的抑制可以调节其功能，从而下调炎症反应。IRAK inhibitor 4是一种吲唑（indazole）类抑制剂。作为IRAK-4的抑制剂，咪唑并[1,2-b]哒嗪（imidazo[1,2-b]pyridazines）和吲唑（indazole）被用于治疗一些炎症、细胞增殖性和免疫相关疾病[1]。
参考文献：
[1] Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh. IRAK-4 Inhibitors for Inflammation. Current Topics in Medicinal Chemistry. 2009, 9: 724-737.
| Storage | Store at -20°C |
| M.Wt | 620.66 |
| Cas No. | 1012104-68-5 |
| Formula | C33H35F3N6O3 |
| Solubility | Soluble in DMSO |
| Chemical Name | 1-(4-hydroxycyclohexyl)-N-(3-methylbutyl)-2-[[5-[2-(trifluoromethoxy)phenyl]-1H-indazol-3-yl]amino]benzimidazole-5-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | CC(C)CCNC(=O)C1=CC2=C(C=C1)N(C(=N2)NC3=NNC4=C3C=C(C=C4)C5=CC=CC=C5OC(F)(F)F)C6CCC(CC6)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | IRAK inhibitor 4是白细胞介素-1受体相关激酶（IRAK，interleukin-1 receptor-associated kinase）抑制剂。 | |||||
| 靶点 | IRAK | |||||
| IC50 | ||||||
化学结构
