TGF-β / Smad Signaling - CDK1/CyclinB - PKC
The TGF-β family is generally classified into two sub-families, TGF-β ligands, and bone morphogenic protein (BMP) ligands. In canonical signaling, receptor activation lead to phosphorylation of a group of transcription factors called Smads. TGF-β ligands bind to type II receptors (TGF-β II) which recruit and phosphorylate type I receptor (TGF-β I) on serine/threonine residues. The TGF-β I then recruits and phosphorylates a receptor regulated Smad (R-Smad). The R-Smad binds to the common Smad (Co-Smad) and forms a heterodimeric complex. This complex then translocates into the cell nucleus where it binds with nuclear co-factors to regulate the transcription of various target genes. Dysregulation of TGF-β/Smad signaling pathway is associated with a number of pathological conditions including fibrosis, cancer, immunodeficiency, diabetes and cardiovascular diseases etc.
- B6803 Rottlerin1 Citation中文名: 揪毒素Target: PKC|Ca2 /calmodulin-dependent protein kinases (CaMKs)|PRAK|MAPKAP-K2Summary: PKC抑制剂
- B3709 Midostaurin (PKC412)中文名: 米哚妥林Target: PKC|PKA|KDR|Flk1|PPK|c-Syk|CDK1/CyclinBSummary: PKC抑制剂
- B2191 Dequalinium Chloride中文名: 地喹氯铵Target: PKC|Calcium-Activated Potassium (KCa) ChannelsSummary: PKC抑制剂
- B1287 Ro 31-8220Target: PKCSummary: Pan-PKC抑制剂
- A8525 Sotrastaurin (AEB071)Target: PKCSummary: PKC抑制剂
- A8344 K-252cTarget: PKC|PKASummary: 蛋白激酶抑制剂
- A8342 GF 109203X1 Citation中文名: 双吲哚马来酰亚胺 ITarget: PKCSummary: Protein kinase C、MLCK、PKG和PKA 的抑制剂
- A8341 Go 6976Target: PKCSummary: PKC α/PKC β1抑制剂
- A1670 Enzastaurin (LY317615)2 Citation中文名: 恩扎妥林Target: PKCSummary: PKCβ抑制剂
- A3306 Chelerythrine Chloride中文名: 白屈菜赤碱Target: PKCSummary: PKC拮抗剂