Proteases - Thymidylate Synthase - Elastases - Aminopeptidases
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A8621 Bestatin hydrochloride中文名: 盐酸乌苯美司Target: AminopeptidasesSummary: 氨肽酶N(APN/CD13)和氨肽酶B抑制剂。
- A4430 Sivelestat sodium salt中文名: 西维来司钠Target: ElastasesSummary: 白细胞弹性蛋白酶抑制剂
- A4355 Tosedostat (CHR2797)1 Citation中文名: 托舍多特Target: AminopeptidasesSummary: 氨肽酶(Aminopeptidase)抑制剂
- A4071 Fluorouracil (Adrucil)3 Citation中文名: 氟尿嘧啶Target: Thymidylate SynthaseSummary: 胸苷酸合成酶抑制剂,抗肿瘤药物。
- A2575 Bestatin中文名: 乌苯美司Target: AminopeptidasesSummary: 氨肽酶抑制剂