Proteases - Cathepsins - Serine Proteases - Notch
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A2487 Odanacatib (MK-0822)中文名: 奥当卡替Target: CathepsinsSummary: 组织蛋白酶K抑制剂
- A8239 CA-074 Me7 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A4424 SID 26681509Target: CathepsinsSummary: 人组织蛋白酶L抑制剂
- A4412 MDL 28170Target: Cathepsins|CalpainsSummary: Calpain和cathepsin B抑制剂
- A3284 Cathepsin S inhibitor1 CitationTarget: CathepsinsSummary: 抑制MHCII抗原呈递
- A1926 CA 0742 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A4023 LY30394781 CitationTarget: NotchSummary: Notch抑制剂
- A2587 PMSF1 Citation中文名: 苯甲基磺酰氟Target: Serine ProteasesSummary: 丝氨酸蛋白酶不可逆抑制剂
- A2602 Calpain Inhibitor I, ALLN2 CitationTarget: Cathepsins|CalpainsSummary: Calpain I/II/ B/L抑制剂
- A2576 E-642 CitationTarget: Cathepsins|Calpains|PapainsSummary: 半胱氨酸蛋白酶(cysteine protease)抑制剂