PI3K/Akt/mTOR Signaling - Cyclin-Dependent Kinases - p70 rsk - CK2
The PI3K/Akt/mTOR signaling pathway is a key regulator in growth, survival, cell cycle proliferation, protein synthesis and glucose metabolism. Growth factors, hormones, and cytokines can activate this pathway by binding their cognate receptor tyrosine kinase (RTK), cytokine receptor, or GPCR, resulting in the activation of lipid kinase PI3K which produces PIP3 at the plasma membrane.
The binding of PIP3 translocates Akt to cell membranes, enables Akt activation through phosphorylation at Thr308 mediated by phosphoinositide dependent kinase 1 (PDK1). In addition, Akt is phosphorylated at Ser473 by the mTOR-rictor complex, mTORC2. PTEN is a negative regulator of Akt signaling that reverses the function of PI3K by removing 3’-phosphate groups. Akt activity is also negatively regulated by the phosphatases PP2A and PHLPP. Akt propagates its signal to affect DNA transcription, cell cycle and apoptosis. Akt can activate mTOR directly by phosphorylation or indirectly, by phosphorylation and inactivation of mTOR inhibitor TSC2 and PRAS40. Together these mechanisms stimulate cell growth and G1 cell cycle progression through signaling via p70 S6 Kinase and inhibition of 4E-BP1. Defects in PI3K/AKT/mTOR signaling are implicated in cancer, diabetes and cardiovascular disease etc.
- B5815 LY2584702Target: p70 rskSummary: P70 S6激酶抑制剂
- B3672 Indirubin中文名: 靛玉红Target: Cyclin-Dependent Kinases|GSK-3Summary: 细胞周期蛋白依赖性激酶和GSK-3β抑制剂
- B2228 PF-47086711 CitationTarget: p70 rskSummary: P70 S6K1亚型抑制剂
- A8616 A-674563Target: Cyclin-Dependent Kinases|Akt|GSK-3|ERK|PKC|PKA|RSKSummary: Akt1 / PKA / CDK2的强效选择性抑制剂
- A5653 AT7867Target: Akt|PKA|p70 rskSummary: Akt1/2/3和p70S6K/PKA的抑制剂
- A3894 TTP 221 CitationTarget: CK2Summary: CK2抑制剂
- A3861 TBB1 CitationTarget: CK2Summary: 酪蛋白激酶-2(CK2)抑制剂
- A3368 DMAT2 CitationTarget: Pim|CK2|HIPK2|HIPK3Summary: CK2抑制剂