TBB
Catalog No.
A3861
酪蛋白激酶-2（CK2）抑制剂
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TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.
- 1. Yang PM, Hong YH, et al. "Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units." Oxid Med Cell Longev. 2020 Apr 4;2020:7289120. PMID:32322337
- 2. Zhao Z, Wang L, et al."Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia." Genes Dev. 2019 Jan 1;33(1-2):61-74. PMID:30573454
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 434.71 |
| Cas No. | 17374-26-4 |
| Formula | C6HBr4N3 |
| Synonyms | NSC 231634; TBB (enzyme inhibitor);1H-Benzotriazole, 4,5,6,7-tetrabromo- |
| Solubility | insoluble in H2O; ≥159.2 mg/mL in DMSO; ≥10.42 mg/mL in EtOH with ultrasonic |
| Chemical Name | 4,5,6,7-tetrabromo-2H-benzotriazole |
| SDF | Download SDF |
| Canonical SMILES | C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
相关生物数据
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