Metabolism - Prostate Cancer - Glioma - Pancreatic Carcinoma - Erectile Dysfunction
Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.
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- B4900 Indoximod (NLG-8189)Summary: 吲哚胺2,3-双加氧酶(IDO)途径抑制剂
- B3439 Udenafil中文名: 乌地那非Target: Phosphodiesterases (PDEs)Summary: PDE5抑制剂
- A3358 DeltarasinTarget: Phosphodiesterases (PDEs)Summary: KRAS-PDEδ相互作用抑制剂
- A4334 Avanafil中文名: 阿伐那非Target: Phosphodiesterases (PDEs)Summary: PDE5抑制剂
- A4327 Tadalafil中文名: 他达拉非Target: Phosphodiesterases (PDEs)Summary: PDE5抑制剂
- A4323 Vardenafil HCl Trihydrate中文名: 盐酸伐地那非三水合物Target: Phosphodiesterases (PDEs)Summary: PDE5抑制剂
- A4316 Ketoconazole中文名: 酮康唑Target: Cytochrome P450 (CYP450)Summary: 环孢菌素氧化酶和睾酮6β-羟化酶的抑制剂
- A8202 Abiraterone acetate中文名: 乙酸阿比特龙酯Target: Cytochrome P450 (CYP450)Summary: 细胞色素p450 17a1抑制剂
- A4065 PF-04929113 (SNX-5422)Target: HSP90Summary: Hsp90抑制剂
- A4061 IPI-504 (Retaspimycin hydrochloride)3 Citation中文名: 瑞他霉素盐酸盐Target: HSP90Summary: Hsp90抑制剂