Membrane Transporter/Ion Channel - NHE - CFTR - GABAA Receptors - Delayed rectifier outward potassium current (IKr)
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B5895 CARIPORIDE中文名: 卡立泊来德Target: NHESummary: 有效的NHE抑制剂
- B1087 GlyH-101Target: CFTRSummary: CFTR Inhibitor II
- A8637 IOWH-032Target: CFTRSummary: CFTR抑制剂
- A8417 Dofetilide2 Citation中文名: 多非利特Target: Delayed rectifier outward potassium current (IKr)Summary: 钾通道抑制剂
- A8435 Furosemide中文名: 呋塞米Target: Na /K /Cl- Symporters (NKCCs)|GABAA ReceptorsSummary: GABAA受体拮抗剂
- A8351 VX-809中文名: 鲁玛卡托Target: CFTRSummary: CFTR调节剂
- A2664 VX-661Target: CFTRSummary: F508del CFTR校正子
- A2917 Flumazenil中文名: 氟马西尼Target: GABAA ReceptorsSummary: 苯二氮卓拮抗剂