Furosemide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
呋塞米(furosemide)是一种Na+/2Cl-/K+协同转运蛋白抑制剂[1].
Na-K-Cl协同转运蛋白(NKCC)是一种协助Na+\K+和Cl-进出细胞的主动转运体.NKCC1在分泌体液的器官里具有重要作用.NKCC2存在于肾脏中,用于从尿液中提取Na+\K+和Cl-[2].
呋塞米(furosemide)是Na+/2Cl-/K+协同转运蛋白的拮抗剂.在成人脑组织中,呋塞米(furosemide)通过抑制细胞肿胀阻断癫痫样活动,并同时抑制活动驱动的细胞间隙变化(ECS)[1].呋塞米(furosemide)抑制外周单核细胞产生和释放细胞因子IL-6\IL-8和TNF-ɑ,从而显示出抗炎活性[3].
在肝硬化患者中,呋塞米(furosemide)抑制钠的作用,并提高心钠素(ANF)和循环内皮素的水平.在新生儿中,呋塞米(furosemide)显著增加醛固酮和内皮素-1的尿排泄[3].
参考文献：
[1]. Hochman DW. The extracellular space and epileptic activity in the adult brain: explaining the antiepileptic effects of furosemide and bumetanide. Epilepsia, 2012, 53 Suppl 1: 18-25.
[2]. Chen H, Sun D. The role of Na-K-Cl co-transporter in cerebral ischemia. Neurol Res, 2005, 27(3): 280-286.
[3]. Prandota J. Furosemide: progress in understanding its diuretic, anti-inflammatory, and bronchodilating mechanism of action, and use in the treatment of respiratory tract diseases. Am J Ther, 2002, 9(4): 317-328.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 330.74 |
| Cas No. | 54-31-9 |
| Formula | C12H11ClN2O5S |
| Solubility | insoluble in H2O; ≥13.35 mg/mL in EtOH; ≥14.9 mg/mL in DMSO |
| Chemical Name | 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid |
| SDF | Download SDF |
| Canonical SMILES | C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
