Membrane Transporter/Ion Channel - P-glycoprotein (P-gp) - Myosin - 5-HT receptors
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B2249 Lamotrigine1 Citation中文名: 拉莫三嗪Target: 5-HT receptors|sodium channelSummary: 5-HT抑制剂,钠通道阻断剂
- A8549 LY335979 (Zosuquidar 3HCL)1 Citation中文名: 唑喹达三盐酸盐Target: P-glycoprotein (P-gp)Summary: Pgb(P糖蛋白)抑制剂
- A8349 Omecamtiv mecarbilTarget: MyosinSummary: 心肌肌球蛋白激活剂
- A3956 ZosuquidarTarget: P-glycoprotein (P-gp)|Cytochrome P450 (CYP450)Summary: MDR调节剂
- A3859 Tariquidar methanesulfonate, hydrate中文名: 他立喹达二甲磺酸盐六水合物Target: P-glycoprotein (P-gp)Summary: P-糖蛋白抑制剂
- A8208 Tariquidar2 Citation中文名: 他立喹达Target: P-glycoprotein (P-gp)Summary: P-糖蛋白抑制剂