Membrane Transporter/Ion Channel - Calcium-activated chloride channels (CaCC) - Cytochrome P450 (CYP450) - AMPA - GABAB Receptors
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B5086 CGP 55845 hydrochlorideTarget: GABAB ReceptorsSummary: GABAB受体拮抗剂
- B7590 Quinidine中文名: 奎尼丁Target: Voltage-gated Sodium (NaV) Channels|Cytochrome P450 (CYP450)Summary: 降低Na+和K+通道电流
- B6367 NPPBTarget: Calcium-activated chloride channels (CaCC)|GPR35Summary: 氯离子通道抑制剂
- B4658 LY451395Target: AMPASummary: 变构调节剂
- B1531 (R)-baclofen中文名: (R)-巴氯芬Target: GABAB ReceptorsSummary: GABA受体激动剂
- A3956 ZosuquidarTarget: P-glycoprotein (P-gp)|Cytochrome P450 (CYP450)Summary: MDR调节剂