Membrane Transporter/Ion Channel - CFTR - F1 Fo-ATPase - GPR35 - TRPA
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B6367 NPPBTarget: Calcium-activated chloride channels (CaCC)|GPR35Summary: 氯离子通道抑制剂
- B1087 GlyH-101Target: CFTRSummary: CFTR Inhibitor II
- B2100 HC-030031Target: TRPASummary: TRPA1通道阻断剂
- B3041 BTB06584Target: F1 Fo-ATPaseSummary: F1F0 ATP合酶抑制剂
- A8637 IOWH-032Target: CFTRSummary: CFTR抑制剂
- A8351 VX-809中文名: 鲁玛卡托Target: CFTRSummary: CFTR调节剂
- A2664 VX-661Target: CFTRSummary: F508del CFTR校正子