DNA Damage/DNA Repair - telomerase - DNA-PK - STAT - TNKS - PHF
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- A8649 NU 7026Target: PI3K|DNA-PK|ATMSummary: 有效的、竞争性DNA-PK抑制剂
- A8626 ETP-46464Target: PI3K|mTOR|DNA-PK|ATM/ATRSummary: ATR抑制剂
- A8317 Fludarabine Phosphate (Fludara)2 Citation中文名: 磷酸氟达拉滨Target: STATSummary: 抑制STAT1激活和DNA合成
- A8315 NU7441 (KU-57788)4 CitationTarget: PI3K|DNA-PKSummary: DNA-PK抑制剂
- A1769 KU-00606481 CitationTarget: PI3K|DNA-PKSummary: DNA-PK/PI3-K双重抑制剂
- A1877 XAV-9391 CitationTarget: TNKSSummary: Tankyrase 1/2抑制剂
- A1945 BIBR 15322 CitationTarget: telomeraseSummary: 端粒酶新型的选择性抑制剂
- A3348 Daminozide中文名: 丁酰肼Target: KDM|PHFSummary: KDM2A抑制剂