Cell Cycle/Checkpoint - Myosin light chain kinases (MLCKs) - ROCK
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B3523 Fasudil中文名: 法舒地尔Target: ROCK|PKC|PKG|PKA|Myosin light chain kinases (MLCKs)Summary: 钙拮抗剂
- B1294 SR-3677Target: ROCKSummary: Rho激酶(ROCK-II)抑制剂
- B1293 Y-276329 CitationTarget: ROCKSummary: ROCK选择性抑制剂
- A5734 Fasudil (HA-1077) HCl1 Citation中文名: 盐酸法舒地尔Target: ROCKSummary: 蛋白激酶抑制剂
- A5611 GSK429286ATarget: ROCKSummary: 选择性ROCK1/ROCK2抑制剂
- A5506 ThiazovivinTarget: ROCKSummary: ROCK抑制剂
- A3825 SLx-21191 CitationTarget: ROCKSummary: ROCK2抑制剂
- A3771 RKI-1447Target: ROCKSummary: ROCK1/ROCK2抑制剂
- A3478 Hydroxyfasudil中文名: 羟基法舒地尔Target: ROCK|Rho-kinaseSummary: Rho激酶抑制剂和血管扩张剂
- A3008 Y-27632 dihydrochloride19 CitationTarget: ROCKSummary: ROCK1抑制剂