Cell Cycle/Checkpoint - Lung Cancer - Liver Cancer
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B3694 K-Ras(G12C) inhibitor 6Target: KRAS G12CSummary: K-Ras (G12C)抑制剂
- B2169 IPA-31 CitationTarget: PAKSummary: 非竞争性Pak1抑制剂
- B1383 VE-8222 CitationTarget: ATM/ATRSummary: ATR抑制剂
- A1493 ABT-751 (E7010)1 CitationTarget: Microtubules/TubulinsSummary: 微管聚合抑制剂,抗有丝分裂。
- A3716 PF-37583091 CitationTarget: PAKSummary: PAK4抑制剂
- A4393 Paclitaxel (Taxol)4 Citation中文名: 紫杉醇Target: Microtubules/TubulinsSummary: 抗肿瘤药
- A4127 GSK1070916Target: Aurora KinasesSummary: Aurora B/C抑制剂
- A4112 Barasertib (AZD1152-HQPA)3 Citation中文名: 巴拉塞替Target: Aurora KinasesSummary: Aurora Kinase B抑制剂