Stem Cell - MST - GSK-3
In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.
- A8735 XMU-MP-12 CitationTarget: MSTSummary: MST1/2的强效选择性抑制剂
- B1536 AZD10801 CitationTarget: GSK-3Summary: GSK3β抑制剂
- A8396 CHIR-99021 (CT99021) HClTarget: GSK-3Summary: GSK-3α/β抑制剂
- A8395 CHIR-98014Target: GSK-3Summary: GSK-3β抑制剂
- A8240 SB 2167633 CitationTarget: GSK-3Summary: GSK-3抑制剂
- A3570 LY2090314Target: GSK-3Summary: 有效的GSK-3抑制剂
- A3184 AR-A0144182 CitationTarget: GSK-3Summary: GSK3β抑制剂
- A3011 CHIR-99021 (CT99021)2 CitationTarget: GSK-3Summary: GSK-3抑制剂