Proteases - Rheumatoid Arthritis - HIV Infections
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A8238 VX-7651 Citation中文名: 贝纳卡森Target: CaspasesSummary: 有效的Caspase-1选择性抑制剂
- A3284 Cathepsin S inhibitor1 CitationTarget: CathepsinsSummary: 抑制MHCII抗原呈递
- A1926 CA 0742 CitationTarget: CathepsinsSummary: Cathepsin B抑制剂
- A8204 Lopinavir中文名: 洛匹那韦Summary: HIV蛋白酶抑制剂
- A4069 BMS-707035Target: HIV IntegrasesSummary: HIV-1整合酶抑制剂