Neuroscience - adrenergic receptor - Inositol-requiring enzyme 1 (IRE1) - 5-HT7 Receptors - COX
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B5624 STF 083010Target: Inositol-requiring enzyme 1 (IRE1)Summary: IRE1α核酸内切酶抑制剂
- B1572 LatrepirdineTarget: Voltage-gated Calcium Channels (CaV)|NMDA receptor|adrenergic receptor|Histamine receptors|GluR|5-HT receptor|dopamine receptors|AMPA receptorSummary: 脑细胞死亡抑制剂
- B1445 Flunixin Meglumin中文名: 氟尼辛葡甲胺Target: COXSummary: 环氧合酶抑制剂
- B1441 Lornoxicam中文名: 氯诺昔康Target: COXSummary: COX-1/COX-2抑制剂
- B1458 Lumiracoxib中文名: 罗美昔布Target: COXSummary: 新型的选择性COX-2抑制剂
- B1447 Ketorolac tromethamine salt中文名: 酮咯酸氨丁三醇Target: COXSummary: 非选择性COX抑制剂
- B1477 Lurasidone HCl中文名: 盐酸鲁拉西酮Target: 5-HT2 Receptors|D2 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺D2/5-HT2A/5-HT7/5-HT1A抑制剂
- B1490 Quetiapine Fumarate1 Citation中文名: 富马酸奎硫平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺受体拮抗剂
- B1454 Rofecoxib中文名: 罗非昔布Target: COXSummary: COX-2抑制剂
- B1459 Valdecoxib中文名: 代他考昔Target: COXSummary: COX-2抑制剂