Neuroscience - AChE - 5-HT1 Receptors - 5-HT1 Receptor - COX
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B4981 SumatriptanTarget: 5-HT1 ReceptorsSummary: 5-HT1受体激动剂
- B6506 SCH 23390 hydrochlorideTarget: dopamine receptor|5-HT1 Receptor|5-HT2 ReceptorSummary: 多巴胺受体拮抗剂
- B6457 8-Hydroxy-PIPAT oxalateTarget: 5-HT1 ReceptorsSummary: 5-HT1A受体激动剂
- B6337 8-Hydroxy-DPAT hydrobromideTarget: 5-HT1 ReceptorsSummary: 5-HT1A激动剂
- B1445 Flunixin Meglumin中文名: 氟尼辛葡甲胺Target: COXSummary: 环氧合酶抑制剂
- B1441 Lornoxicam中文名: 氯诺昔康Target: COXSummary: COX-1/COX-2抑制剂
- B1458 Lumiracoxib中文名: 罗美昔布Target: COXSummary: 新型的选择性COX-2抑制剂
- B2251 Naratriptan中文名: 盐酸那拉曲坦,盐酸纳拉曲坦Target: 5-HT1 ReceptorSummary: 选择性5-HT1受体亚型激动剂
- B1447 Ketorolac tromethamine salt中文名: 酮咯酸氨丁三醇Target: COXSummary: 非选择性COX抑制剂
- B1477 Lurasidone HCl中文名: 盐酸鲁拉西酮Target: 5-HT2 Receptors|D2 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺D2/5-HT2A/5-HT7/5-HT1A抑制剂