Neuroscience - Gap Junctions - Histamine H4 Receptors - EAA receptor - TRPC channel
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A3316 Clemizole hydrochloride中文名: 盐酸克立咪唑Target: Histamine H1 Receptors|TRPC channelSummary: H1组胺受体拮抗剂
- A1045 Gap 274 CitationTarget: Gap JunctionsSummary: 缝隙连接阻断剂
- A1044 Gap 268 CitationTarget: Gap JunctionsSummary: 间隙连接阻断肽,对应于connexin 43的63-75 aa。
- B7026 4-Methylhistamine dihydrochlorideTarget: Histamine H4 ReceptorsSummary: H4受体激动剂
- B6227 Kynurenic acid中文名: 犬尿酸Target: EAA receptorSummary: 广谱EAA拮抗剂
- B1574 JNJ-7777120Target: Histamine H4 ReceptorsSummary: 组胺H4受体拮抗剂
- A8389 Carbenoxolone disodium1 CitationTarget: Gap JunctionsSummary: 11β-HSD抑制剂
- A2700 10Panx1 CitationTarget: Gap JunctionsSummary: Panx-1模拟抑制肽