Neuroscience - Gap Junctions - Histamine H4 Receptors - DREADD Ligands - SERT
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A1045 Gap 274 CitationTarget: Gap JunctionsSummary: 缝隙连接阻断剂
- A1044 Gap 268 CitationTarget: Gap JunctionsSummary: 间隙连接阻断肽,对应于connexin 43的63-75 aa。
- B7026 4-Methylhistamine dihydrochlorideTarget: Histamine H4 ReceptorsSummary: H4受体激动剂
- B1574 JNJ-7777120Target: Histamine H4 ReceptorsSummary: 组胺H4受体拮抗剂
- A8389 Carbenoxolone disodium1 CitationTarget: Gap JunctionsSummary: 11β-HSD抑制剂
- A3926 Vortioxetine中文名: 沃替西汀Target: 5-HT1 Receptors|5-HT7 Receptors|5-HT3 Receptors|SERTSummary: 5-HT受体拮抗剂
- A3317 Clozapine N-oxide(CNO)1 Citation中文名: 氯氮平的N-氧化物Target: DREADD LigandsSummary: Clozapine代谢产物,用于化学遗传学
- A2700 10Panx1 CitationTarget: Gap JunctionsSummary: Panx-1模拟抑制肽