Neuroscience - 5-HT2 Receptors - COX
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B2248 Ketanserin中文名: 酮色林Target: 5-HT2 ReceptorsSummary: 特异性5-HT2A受体拮抗剂
- B1445 Flunixin Meglumin中文名: 氟尼辛葡甲胺Target: COXSummary: 环氧合酶抑制剂
- B1441 Lornoxicam中文名: 氯诺昔康Target: COXSummary: COX-1/COX-2抑制剂
- B1458 Lumiracoxib中文名: 罗美昔布Target: COXSummary: 新型的选择性COX-2抑制剂
- B2231 Amitriptyline HCl中文名: 盐酸阿米替林Target: Trk Receptors|5-HT2 Receptors|Norepinephrine transporter|5-HT TransportersSummary: 血清素/去甲肾上腺素受体/5-HT4/5-HT2抑制剂
- B1447 Ketorolac tromethamine salt中文名: 酮咯酸氨丁三醇Target: COXSummary: 非选择性COX抑制剂
- B2007 Pizotifen Malate中文名: 苹果酸苯噻Target: 5-HT2 Receptors|D2 ReceptorsSummary: 5-HT受体拮抗剂
- B1206 Pizotifen中文名: 苯噻啶Target: 5-HT2 ReceptorsSummary: 高选择性5-HT受体阻断剂
- B1477 Lurasidone HCl中文名: 盐酸鲁拉西酮Target: 5-HT2 Receptors|D2 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺D2/5-HT2A/5-HT7/5-HT1A抑制剂
- B1490 Quetiapine Fumarate1 Citation中文名: 富马酸奎硫平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺受体拮抗剂