Neuroscience - Cell Experiments - Glioblastoma - Inflammatory Diseases - Cancer
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B5624 STF 083010Target: Inositol-requiring enzyme 1 (IRE1)Summary: IRE1α核酸内切酶抑制剂
- B1564 Ranitidine中文名: 盐酸雷尼替丁Target: Histamine H2 ReceptorsSummary: 组胺H2受体拮抗剂
- B2231 Amitriptyline HCl中文名: 盐酸阿米替林Target: Trk Receptors|5-HT2 Receptors|Norepinephrine transporter|5-HT TransportersSummary: 血清素/去甲肾上腺素受体/5-HT4/5-HT2抑制剂
- A8449 Indomethacin中文名: 吲哚美辛Target: COXSummary: Cox抑制剂
- A8446 Ibuprofen中文名: 布洛芬Target: COXSummary: 生物学活性
- A5166 Ondansetron HCl中文名: 盐酸昂丹司琼Target: 5-HT3 ReceptorsSummary: 5-HT3受体拮抗剂
- A1684 Aprepitant中文名: 阿瑞匹坦Target: Substance P/NK1 ReceptorSummary: P物质(SP)抑制剂
- A2960 Loratadine中文名: 氯雷他定Target: Histamine H1 ReceptorsSummary: 外周HH1R拮抗剂
- A3136 A-740003Target: P2X ReceptorsSummary: P2X7受体拮抗剂