Metabolism - complex I of the mitochondrial electron transport chain - Phosphodiesterases (PDEs) - Inward Rectifier Potassium (Kir) Channels - Phospholipases
Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.
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- B6988 BRL 50481Target: Phosphodiesterases (PDEs)Summary: PDE7抑制剂
- B6304 Etazolate hydrochloride2 CitationTarget: Phosphodiesterases (PDEs)Summary: PDE-4抑制剂和选择性GABA-A受体调节剂
- B5462 Rotenone中文名: 鱼藤酮Target: complex I of the mitochondrial electron transport chainSummary: 线粒体复合物I电子传递链抑制剂
- B3439 Udenafil中文名: 乌地那非Target: Phosphodiesterases (PDEs)Summary: PDE5抑制剂
- B1296 Glibenclamide中文名: 格列本脲Target: Inward Rectifier Potassium (Kir) ChannelsSummary: 胰岛素生产调节剂
- B1386 Milrinone中文名: 米力农Target: Phosphodiesterases (PDEs)Summary: PDE3抑制剂
- B2276 Vinpocetine中文名: 长春西汀Target: Phosphodiesterases (PDEs)Summary: PDE抑制剂
- A3358 DeltarasinTarget: Phosphodiesterases (PDEs)Summary: KRAS-PDEδ相互作用抑制剂
- A4356 Varespladib (LY315920)中文名: 伐瑞拉迪Target: PhospholipasesSummary: HnsPLA的强效选择性抑制剂
- A4346 Aminophylline中文名: 氨茶碱,氨基非林Target: Phosphodiesterases (PDEs)Summary: Pan-PDE抑制剂