Membrane Transporter/Ion Channel - CFTR - benzodiazepine receptor - NHE
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B5895 CARIPORIDE中文名: 卡立泊来德Target: NHESummary: 有效的NHE抑制剂
- B6401 PK 111951 CitationTarget: benzodiazepine receptorSummary: 外周苯二氮卓拮抗剂
- B1087 GlyH-101Target: CFTRSummary: CFTR Inhibitor II
- A8637 IOWH-032Target: CFTRSummary: CFTR抑制剂
- A8351 VX-809中文名: 鲁玛卡托Target: CFTRSummary: CFTR调节剂
- A2664 VX-661Target: CFTRSummary: F508del CFTR校正子