DNA Damage/DNA Repair - Leukemia - Glioma - Lung Cancer
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B3589 5-BrdU中文名: 溴尿苷Summary: 胸腺嘧啶核苷类似物
- B1963 Lomustine1 Citation中文名: 洛莫司汀Target: RNA synthesisSummary: 抗肿瘤药
- B1383 VE-8222 CitationTarget: ATM/ATRSummary: ATR抑制剂
- A8405 Cytarabine1 Citation中文名: 阿糖胞苷Summary: cytotoxic agent, blocks DNA synthesis
- A8336 KU-600192 CitationTarget: ATM/ATRSummary: ATM激酶抑制剂
- A8317 Fludarabine Phosphate (Fludara)2 Citation中文名: 磷酸氟达拉滨Target: STATSummary: 抑制STAT1激活和DNA合成
- A5424 Fludarabine中文名: 氟达拉滨Summary: DNA合成抑制剂
- A1379 Nelarabine中文名: 奈拉滨Summary: 针对T-LBL/ T-ALL的ara-G前体药物
- A2451 Epirubicin HCl中文名: 盐酸表阿霉素Target: TopoisomerasesSummary: 抗生素类抗肿瘤药物
- A1971 Etoposide4 Citation中文名: 依托泊苷Target: TopoisomerasesSummary: 拓扑异构酶II(Topo II)抑制剂