DNA Damage/DNA Repair - Breast Cancer - Colorectal Cancer - Inflammatory Diseases - Melanoma
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B4896 BMH-21Target: RNA PolymerasesSummary: RNA聚合酶I抑制剂
- B7336 Thiostrepton中文名: 硫链丝菌素Target: FoxM1Summary: 抑制细菌蛋白合成的抗生素
- B1476 Raltitrexed中文名: 雷替曲塞Target: Thymidylate SynthaseSummary: 胸苷酸合酶抑制剂
- B1474 FT-207 (NSC 148958)中文名: 替加氟Summary: DNA/RNA合成抑制剂
- B2293 Irinotecan HCl Trihydrate中文名: 盐酸依立替康三水合物Target: TopoisomerasesSummary: 拓扑异构酶I抑制剂
- B1963 Lomustine1 Citation中文名: 洛莫司汀Target: RNA synthesisSummary: 抗肿瘤药
- A8624 CGK733Target: ATM/ATRSummary: ATM/ATR抑制剂
- A2451 Epirubicin HCl中文名: 盐酸表阿霉素Target: TopoisomerasesSummary: 抗生素类抗肿瘤药物
- A1402 Gemcitabine HCl中文名: 盐酸吉西他滨Summary: 抑制DNA合成,脱氧胞苷类似物
- A2402 Floxuridine中文名: 氟尿苷Target: Synthases/SynthetasesSummary: 抗肿瘤抗代谢物