Cell Cycle/Checkpoint - folate receptor - VEGFR - PTEN - Aurora Kinases
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B4787 SF1670Target: PTENSummary: PTEN抑制剂
- A8807 MK-8745Target: Aurora KinasesSummary: Aurora A的强效选择性抑制剂。
- A4489 TC-A 2317 hydrochlorideTarget: Aurora KinasesSummary: Aurora kinase A抑制剂
- A3760 Reversine中文名: 逆转素Target: Aurora KinasesSummary: Aurora激酶抑制剂
- A3214 AZD11521 CitationTarget: Aurora KinasesSummary: Aurora B激酶抑制剂
- A4128 PF-03814735Target: Aurora KinasesSummary: Aurora A/B抑制剂
- A4127 GSK1070916Target: Aurora KinasesSummary: Aurora B/C抑制剂
- A4126 Aurora A Inhibitor I中文名: 极光A抑制剂ITarget: Aurora KinasesSummary: Aurora A抑制剂
- A4125 CYC116Target: Aurora Kinases|FLT3|VEGFRSummary: Aurora A/B抑制剂
- A4124 TAK-901Target: Aurora Kinases|FLT3|Src|JAK|LRRK2|Hck|FGR|YES|Fyn|ARGSummary: Aurora A/B抑制剂