Cell Cycle/Checkpoint - Cell Experiments - Ovarian Cancer - Cancer
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- A8316 PD 0332991 (Palbociclib) HCl5 Citation中文名: 帕博西尼Target: Cyclin-Dependent KinasesSummary: CDK4/6抑制剂
- A8300 ZCL2781 CitationTarget: Cdc42Summary: Cdc42抑制剂
- A5719 AT7519Target: Cyclin-Dependent KinasesSummary: CDK抑制剂
- A1352 Zoledronic Acid中文名: 唑来膦酸Target: Farnesyl Diphosphate SynthasesSummary: 含氮二磷酸盐
- A1980 SNS-032 (BMS-387032)2 CitationTarget: Cyclin-Dependent KinasesSummary: CDK抑制剂
- A1765 Vincristine sulfate中文名: 硫酸长春新碱Target: Microtubule/TubulinSummary: 微管的破坏者,抗肿瘤剂
- A3965 BI 25361 CitationTarget: PLK|Bromodomain-containing proteins(BRDs)Summary: ATP竞争性的Plk1抑制剂
- A4489 TC-A 2317 hydrochlorideTarget: Aurora KinasesSummary: Aurora kinase A抑制剂
- A3771 RKI-1447Target: ROCKSummary: ROCK1/ROCK2抑制剂
- A3764 RI-1Target: RAD51Summary: RAD51抑制剂