Tyrosine Kinase - BMP and Other Activin Receptors - c-RET
Receptor tyrosine kinases bind to extracellular ligands/growth factors, which promotes receptor dimerization and autophosphorylation of receptor tyrosine residues. This triggers a cascade of downstream events through phosphorylation of intracellular proteins that ultimately transduce the extracellular signal to the nucleus, causing changes in gene expression. Receptor tyrosine kinases include EGFR/ErbB, PDGFR, VEGFR, FGFR and MET subfamilies etc. Dysfunctions in tyrosine phosphorylation are linked to oncogenic transformation. In additions, various adaptor and effector proteins couple to carboxy-terminal of an active kinase. For instance, binding of the GRB2 adaptor protein activates EGFR and MAPK/ERK signaling.
Non-receptor tyrosine kinases involve many well-defined proteins (e.g. the Src family kinases, c-Abl, and Jak kinases) and other kinases which regulates cell growth and differentiation. For example, Src family kinases are curial for activating and inhibitory pathways in the innate immune response.
- A8889 G-749Target: Aurora Kinases|FLT3|c-RETSummary: FLT3抑制剂
- B3688 ML347Target: BMP and Other Activin ReceptorsSummary: 有效的BMP受体选择性抑制剂
- B3686 DMH-1Target: BMP and Other Activin ReceptorsSummary: BMP ALK2受体抑制剂
- A8324 LDN-193189Target: BMP and Other Activin ReceptorsSummary: ALK抑制剂
- A3750 Regorafenib hydrochloride中文名: 瑞戈非尼盐酸盐Target: Raf|VEGFR|PDGFR|c-Kit|c-RETSummary: 酪氨酸激酶抑制剂